Table X.
HRs and HER2 comparisons between BRCA2 and BRCA- groups (n=373a).
| Molecular markers | BRCA2 (%) | BRCA−b (%) | Univariate P-value | Multivariate P-value | OR (95%CI) |
|---|---|---|---|---|---|
| ER | |||||
| <1% | 2 (6.5) | 120 (35.1) | 0.001 | 0.09 | 0.2 (0.4–1.3) |
| ≥1% | 29 (93.5) | 222 (64.9) | – | ||
| PR | |||||
| <1% | 4 (12.9) | 139 (40.6) | 0.002 | 0.41 | 0.6 (0.2–2.2) |
| ≥1% | 27 (87.1) | 203 (59.4) | – | ||
| HER-2 | |||||
| − | 30 (96.8) | 254 (74.3) | 0.005 | 0.03 | 9.4 (1.3–71.0) |
| + | 1 (3.2) | 88 (25.7) |
HRs, hormone receptors; ER, estrogen receptor; PR, progesterone receptor; HER2, humane epidermal growth factor receptor 2.
a
One BRCA- participant was excluded because of the unclear HER2 state.
b
Wild type BRCA.