Table II.
Expression of HOXA1 and associations with clinicopathological parameters in LUAD based on reverse transcription-quantitative polymerase chain reaction.
| Clinicopathological-features | n | HOXA1 expression (2−∆∆Cq)
|
||
|---|---|---|---|---|
| Fold-change | T-value | P-value | ||
| Tissues | ||||
| Normal lung | 53 | 1.00 | 1.387 | 0.169 |
| LUAD | 31 | 1.291 | ||
| Size, cm | ||||
| ≤3 | 9 | 1.090 | −0.795 | 0.433 |
| >3 | 22 | 1.372 | ||
| TNM | ||||
| I–II | 19 | 1.026 | −2.236 | 0.033 |
| III–IV | 12 | 1.709 | ||
| Sex | ||||
| Male | 23 | 1.214 | −0.812 | 0.423 |
| Female | 8 | 1.509 | ||
| Age, years | ||||
| <60 | 19 | 1.444 | 1.221 | 0.232 |
| ≥60 | 12 | 1.047 | ||
| Smoking | ||||
| No | 17 | 1.440 | 1.033 | 0.310 |
| Yes | 14 | 1.111 | ||
| Vascular invasion | ||||
| No | 29 | 1.300 | 0.176 | 0.861 |
| Yes | 2 | 1.184 | ||
| LNM | ||||
| No | 18 | 0.991 | 0.279 | 0.024 |
| Yes | 13 | 1.705 | ||
| Grade | ||||
| I | 5 | 1.406 | 0.318a | 0.730 |
| II | 23 | 1.316 | ||
| III | 3 | 0.906 | ||
a
F-value. HOXA1, homeobox A1; LUAD, lung adenocarcinoma; TNM, TNM, Tumor-Node-Metastasis; LNM, lymph node metastasis.