Table III.
Expression of HOXA1 and associations with clinicopathological parameters in LUSC based on reverse transcription-quantitative polymerase chain reaction.
| Clinicopathological-features | n | HOXA1 expression (2−∆∆Cq)
|
||
|---|---|---|---|---|
| Fold-change | T-value | P-value | ||
| Tissues | ||||
| Normal lung | 53 | 1.00 | −2.666 | 0.012 |
| LUSC | 22 | 1.872 | ||
| Size, cm | ||||
| ≤3 | 6 | 1.342 | −1.087 | 0.290 |
| >3 | 16 | 2.073 | ||
| TNM | ||||
| I–II | 10 | 0.863 | −4.009 | 0.001 |
| III–IV | 12 | 2.714 | ||
| Sex | ||||
| Male | 17 | 1.932 | 0.341 | 0.736 |
| Female | 5 | 1.679 | ||
| Age, years | ||||
| <60 | 14 | 2.000 | 0.547 | 0.591 |
| ≥60 | 8 | 1.654 | ||
| Smoking | ||||
| No | 12 | 1.761 | −0.404 | 0.690 |
| Yes | 10 | 2.009 | ||
| Vascular invasion | ||||
| No | 19 | 1.809 | −0.525 | 0.605 |
| Yes | 3 | 2.278 | ||
| LNM | ||||
| No | 10 | 0.936 | −3.535 | 0.002 |
| Yes | 12 | 2.654 | ||
| Grade | ||||
| I | 0 | – | 0.417 | 0.526 |
| II | 15 | 1.407 | ||
| III | 7 | 1.585 | ||
HOXA1, homeobox A1; LUSC, lung squamous cell carcinoma; TNM, TNM, Tumor-Node-Metastasis; LNM, lymph node metastasis.