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. 2018 Apr 11;15(6):9069–9074. doi: 10.3892/ol.2018.8467

Figure 3.

Figure 3.

The PI3K/AKT pathway is involved in the PRL-3-mediated invasion and migration of gastric cancer. (A) Migration and (B) invasion were analyzed by Transwell assays. Quantification of (C) migration and (D) invasion prior to and following the addition of LY294002. Each histogram bar indicates the number of stained cells. The experiments were independently repeated ≥3 times. Magnification, ×200. *P<0.05 vs. the control group. Control, SGC7901 cells; vector, SGC7901 cells transfected with control empty vector; high, plasmid SGC7901/EGFP-PRL-3 cells. PI3K, phosphatidylinositol 3-kinase; AKT, RAC serine/threonine-protein kinase; PRL-3, phosphatase of regenerating liver-3; DMSO, dimethyl sulfoxide.