Table 1.
Characteristics of 11 patients with indolent GI TLPD or NK-cell enteropathy
| Patient | Age | Sex | GI site* | CD3 | CD4 | CD5 | CD7 | CD8 | CD56 | TIA1 | GrzB | TCR βF1 | TCR γδ | STAT3-JAK2 fusion | pSTAT1Y701 | pSTAT3Y705 | pSTAT5Y694 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CD4+ GI TLPD | |||||||||||||||||
| 1 | 54 | F | D,J | + | + | + | − | − | − | − | − | + | − | Yes | − | − | + |
| 2 | 48 | F | S,D,J,I | + | + | + | + | − | − | − | − | + | − | Yes | − | − | + |
| 3 | 51 | M | D,J | + | + | + | − | − | − | − | − | + | − | Yes | + | − | + |
| 4 | 70 | M | S,D,J | + | + | − | + | − | − | − | − | + | − | Yes | − | − | − |
| 5 | 51 | M | D,J,I,C | + | + | + | + | − | − | − | − | + | − | No | − | + | − |
| CD8+ GI TLPD | |||||||||||||||||
| 6 | 47 | F | S,D,J,I | + | − | + | − | + | − | + | − | + | − | No | − | − | + |
| 7 | 39 | M | S,D,J,I,C | + | − | + | + | + | − | + | − | + | − | No | − | − | − |
| 8 | 74 | F | D,J | + | − | + | + | + | − | + | − | + | − | No | + | − | − |
| 9 | 57 | M | I | + | − | + | + | + | − | + | − | + | − | No | − | − | − |
| CD4+/CD8+ GI TLPD | |||||||||||||||||
| 10 | 60 | M | D,J | + | + | + | − | + | − | − | − | + | − | No | † | + | † |
| NK-cell enteropathy | |||||||||||||||||
| 11 | 68 | F | S,D,J | + | − | − | − | − | + | + | + | − | − | No‡ | † | − | − |
F, female; M, male.
*
GI sites of involvement: C, colon; D, duodenum; I, ileum ; J, jejunum; S, stomach.
†
Insufficient material or technically uninterpretable.
‡
No fusion reported by FoundationOne Heme testing; FISH studies technically uninterpretable.