EZH2 knockdown inhibited cell proliferation. (A) The endometrial cancer cell HEC-1A and RL95-2 were transfected with three separated EZH2 siRNA or control siRNA respectively. The efficiency of EZH2 knockdown was examined by RT-qPCR. (B) Curves of cell viability were showed 24, 48, 72, 96, 120 h after EZH2-siRNA transfection by CCK8 assay. A significant decrease in proliferation was observed. Results shown are from three independent experiments. *P<0.05; **P<0.01 vs. the control group. EZH2, enhancer of zeste homolog 2; RT-qPCR, quantitative reverse transcription-polymerase chain reaction; si, small interfering.