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TUNEL staining in the (A) control, (B) 20 mg/kg cimetidine, (C) 40 mg/kg cimetidine and (D) 120 mg/kg cimetidine groups (counterstain with Mayer's hematoxylin; magnification, ×400; scale bar, 50 µm). Brown staining indicates TUNEL-positive cells. Obvious TUNEL-positive cells were observed in seminiferous tubules of the 120 mg/kg cimetidine group (arrows). TUNEL, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling.
