Table II.
Effects of cimetidine on sperm parameters of male rats.
| Cimetidine (mg/kg) | ||||
|---|---|---|---|---|
| Parameter | Control | 20 | 40 | 120 |
| Sperm count (106/ml) | 9.1±4.5 | 6.9±2.8 | 5.8±3.1 | 6.0±1.8 |
| Sperm motility (%) | 51.5±20.3 | 60.2±14.5 | 65.3±13.3 | 49.5±11.2 |
| Progressive sperm count (106/ml) | 1.7±1.1 | 1.4±0.8 | 1.3±0.5 | 0.9±0.6 |
| VAP (µm/sec) | 243.2±40.5 | 240.6±24.5 | 249.5±11.6 | 205.5±15.6a |
| VSL (µm/sec) | 167.1±30.7 | 165.9±18.6 | 161.2±9.8 | 139.6±10.6a |
| VCL (µm/sec) | 417.7±80.5 | 412.0±41.6 | 427.1±25.9 | 348.9±31.8a |
a
P<0.05 vs. control group. Values are expressed as the mean ± standard deviation (n=8). VAP, average path velocity of sperm; VSL, straight line velocity of sperm; VCL, curvilinear velocity of sperm.