Table II.
Univariate and multivariate analysis of the risk factors of hepatocellular carcinoma recurrence.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (>60/≤60 years) | 1.096 (0.594–2.023) | 0.769 | ||
| Gender (male/female) | 0.677 (0.318–1.439) | 0.311 | ||
| AFP (>200/≤200 ng/ml) | 0.690 (0.396–1.201) | 0.190 | ||
| BCLC stage (0-A/B-C) | 0.497 (0.282–0.878) | 0.016 | 1.288 (0.657–3.622) | 0.461 |
| Tumor number (1/>1) | 1.080 (0.487–2.397) | 0.850 | ||
| Tumor size | ||||
| Maximum diameter (>5/≤5 cm) | 1.615 (0.936–2.785) | 0.085 | 0.697 (0.369–1.315) | 0.264 |
| Smallest diameter (>3/≤3 cm) | 1.228 (0.713–2.117) | 0.459 | ||
| Differentiation (poor/moderate or well) | 0.714 (0.414–1.233) | 0.229 | ||
| Microvascular invasion (presence/absence) | 1.732 (0.983–3.053) | 0.057 | 2.115 (1.143–3.913) | 0.017a |
| Micrometastases (presence/absence) | 1.083 (0.606–1.933) | 0.788 | ||
| MPC1 expression (low/high) | 3.926 (2.205–6.989) | 0.000 | 3.773 (2.113–6.737) | 0.001a |
| MPC2 expression (low/high) | 1.397 (0.809–2.411) | 0.230 | ||
a
P<0.05. HR, hazard ratio; 95% CI, 95% confidence interval; MPC, mitochondrial pyruvate carrier; AFP, α-fetoprotein.