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. 2018 Apr 10;15(6):9457–9463. doi: 10.3892/ol.2018.8450

Figure 4.

Figure 4.

Oldhamianoside II transcriptionally induces Wnt antagonists. Expression levels of Wnt pathway antagonists, including (A) AXIN2, (B) PPP2CB, (C) DKK1 and (D) SFRP5, were evaluated by reverse transcription-quantitative polymerase chain reaction in VCaP cells following oldhamianoside II treatment. The mRNA expression levels of antagonists of the Wnt signaling pathway were normalized to that of GADPH. *P<0.05 and **P<0.01 vs. vehicle control. AXIN2, axin 2; PPP2CB, protein phosphatase 2 catalytic subunit β; DKK1, Dickkopf-1; SFRP5, secreted frizzled-related protein 5.