Figure 4.

SsnB reduced the expression of MyD88 and NF-κB in perihematomal tissues following ICH. The expression of (A) TLR4 and (B) TRIF in perihematomal tissue following ICH did not differ between the ICH + vehicle and ICH + SsnB groups. Compared with the ICH + vehicle group, SsnB reduced (C) MyD88 and (D) NF-κB expression in perihematomal tissue following ICH. All data are presented as the mean ± standard deviation. Data were obtained for samples pooled from 5 mice, and the experiments were repeated 3 times. *P<0.05 and **P<0.01, n=5. ICH, intracerebral hemorrhage; SsnB, Sparstolonin B; TRIF, TIR-domain-containing adapter-inducing interferon-β; TLR4, toll-like receptor 4; NF-κB, nuclear factor κB; MyD88, myeloid differentiation primary response 88.