. 2018 Apr 17;15(6):9216–9230. doi: 10.3892/ol.2018.8514

Table III.

The association between E2Fs and relapse-free survival for patients with breast cancer based on clinicopathological features.

		Positive status			Negative status

Clinicopathological factor	Gene symbol	Cases	HR (95% CI)	P-value	Cases	HR (95% CI)	P-value
ER	E2F1	1802	1.49 (1.25–1.77)	<0.001^a	671	1.13 (0.88–1.44)	0.332
	E2F2	695	1.35 (0.99–1.85)	0.056	313	0.99 (0.69–1.41)	0.941
	E2F3	1802	1.18 (0.99–1.40)	0.060	671	0.91 (0.71–1.17)	0.461
	E2F4	1802	1.14 (0.96–1.36)	0.131	671	1.05 (0.82–1.35)	0.674
	E2F5	1802	1.13 (0.95–1.34)	0.174	671	0.75 (0.58–0.96)	0.021^a
	E2F6	1802	1.19 (1.00–1.41)	0.052	671	0.75 (0.58–0.96)	0.021^a
	E2F7	695	1.50 (1.09–2.05)	0.011^a	313	1.14 (0.79–1.62)	0.487
	E2F8	1802	1.75 (1.47–2.09)	<0.001^a	671	1.16 (0.91–1.49)	0.227
PR	E2F1	525	1.84 (1.27–2.68)	0.001^a	483	1.10 (0.81–1.49)	0.550
	E2F2	489	1.34 (0.92–1.96)	0.130	372	1.44 (1.00–2.05)	0.046^a
	E2F3	525	1.21 (0.85–1.74)	0.292	483	1.05 (0.77–1.43)	0.756
	E2F4	525	1.24 (0.86–1.78)	0.243	483	1.57 (1.15–2.14)	0.004^a
	E2F5	525	1.20 (0.83–1.71)	0.329	483	1.09 (0.80–1.48)	0.581
	E2F6	525	1.05 (0.73–1.51)	0.777	483	0.79 (0.58–1.08)	0.142
	E2F7	489	1.66 (1.13–2.44)	0.010^a	372	1.02 (0.71–1.45)	0.930
	E2F8	525	2.04 (1.40–2.96)	<0.001^a	483	1.12 (0.82–1.52)	0.482
HER-2	E2F1	168	1.09 (0.65–1.84)	0.737	756	1.61 (1.23–2.10)	<0.001^a
	E2F2	150	0.57 (0.33–0.99)	0.045^a	635	1.80 (1.33–2.44)	<0.001^a
	E2F3	168	1.03 (0.61–1.72)	0.925	756	1.50 (1.15–1.96)	0.003^a
	E2F4	168	1.09 (0.65–1.84)	0.736	756	1.25 (0.96–1.63)	0.099
	E2F5	168	0.67 (0.40–1.14)	0.137	756	1.17 (0.90–1.52)	0.253
	E2F6	168	0.82 (0.48–1.38)	0.453	756	1.09 (0.84–1.42)	0.505
	E2F7	150	0.79 (0.46–1.36)	0.396	635	2.02 (1.48–2.74)	<0.001^a
	E2F8	168	0.96 (0.57–1.62)	0.883	756	1.84 (1.41–2.42)	<0.001^a
Lymph node	E2F1	945	1.44 (1.16–1.80)	0.001^a	1813	1.60 (1.34–1.91)	<0.001^a
	E2F2	665	1.52 (1.16–2.00)	0.003^a	451	1.40 (0.93–2.10)	0.107
	E2F3	945	1.33 (1.07–1.66)	0.011^a	1813	1.47 (1.23–1.75)	<0.001^a
	E2F4	945	1.23 (0.99–1.54)	0.061	1813	1.11 (0.93–1.32)	0.253
	E2F5	945	1.11 (0.89–1.38)	0.349	1813	1.09 (0.91–1.29)	0.343
	E2F6	945	1.06 (0.85–1.32)	0.600	1813	0.95 (0.80–1.13)	0.558
	E2F7	665	1.33 (1.01–1.74)	0.041^a	451	1.89 (1.25–2.86)	0.002^a
	E2F8	945	1.53 (1.22–1.90)	<0.001^a	1813	1.73 (1.45–2.07)	<0.001^a

P<0.05. HR, hazard radio; CI, confidence interval; N/A, not available; HER-2, human epidermal growth factor 2; ER, estrogen receptor; PR, progesterone receptor.