. 2018 Apr 17;15(6):9216–9230. doi: 10.3892/ol.2018.8514

Table IV.

The association between E2Fs and distant metastasis-free survival for patients with breast cancer based on clinicopathological features.

		Positive status			Negative status

Clinicopathological factor	Gene symbol	Cases	HR (95% CI)	P-value	Cases	HR (95% CI)	P-value
ER	E2F1	577	1.89 (1.29–2.75)	<0.001^a	170	1.01 (0.61–1.69)	0.958
	E2F2	161	1.79 (0.69–4.64)	0.221	68	0.79 (0.34–1.83)	0.583
	E2F3	577	1.05 (0.73–1.50)	0.812	170	0.96 (0.57–1.60)	0.867
	E2F4	577	1.38 (0.96–1.97)	0.082	170	0.82 (0.49–1.37)	0.451
	E2F5	577	1.42 (0.99–2.04)	0.057	170	0.59 (0.35–0.99)	0.044^a
	E2F6	577	0.93 (0.65–1.34)	0.707	170	0.51 (0.29–0.87)	0.012^a
	E2F7	161	1.57 (0.61–4.05)	0.348	68	0.69 (0.30–1.62	0.394
	E2F8	577	2.74 (1.86–4.04)	<0.001^a	170	0.84 (0.50–1.41)	0.512
PR	E2F1	122	1.49 (0.43–5.12)	0.522	95	1.35 (0.64–2.83)	0.433
	E2F2	122	0.92 (0.28–3.01)	0.887	95	1.59 (0.75–3.38)	0.224
	E2F3	122	2.32 (0.61–8.85)	0.203	95	0.97 (0.46–2.04)	0.932
	E2F4	122	0.42 (0.11–1.61)	0.193	95	1.90 (0.88–4.08)	0.095
	E2F5	122	3.27 (0.86–12.42)	0.065	95	0.91 (0.43–1.93)	0.808
	E2F6	122	0.60 (0.18–2.03)	0.409	95	0.36 (0.16–0.82)	0.012^a
	E2F7	122	0.79 (0.24–2.60)	0.701	95	1.16 (0.55–2.44)	0.697
	E2F8	122	1.87 (0.55–6.39)	0.311	95	1.56 (0.74–3.30)	0.242
HER-2	E2F1	66	1.12 (0.44–2.82)	0.810	82	1.63 (0.46–5.76)	0.447
	E2F2	66	1.00 (0.40–2.53)	0.996	82	2.38 (0.61–9.20)	0.195
	E2F3	66	1.09 (0.43–2.76)	0.853	82	2.39 (0.62–9.24)	0.193
	E2F4	66	1.33 (0.53–3.36)	0.543	82	0.64 (0.18–2.28)	0.492
	E2F5	66	0.44 (0.17–1.18)	0.092	82	1.58 (0.44–5.59)	0.477
	E2F6	66	0.35 (0.12–0.98)	0.037^a	82	1.55 (0.44–5.50)	0.492
	E2F7	66	0.25 (0.08–0.75)	0.007^a	82	2.43 (0.63–9.39)	0.184
	E2F8	66	1.46 (0.57–3.71)	0.425	82	4.48 (0.95–21.1)	0.038
Lymph node	E2F1	337	1.32 (0.87–2.01)	0.185	896	1.76 (1.32–2.35)	<0.001^a
	E2F2	172	1.52 (0.82–2.84)	0.181	162	1.88 (0.78–4.55)	0.154
	E2F3	337	1.17 (0.77–1.77)	0.462	896	1.49 (1.12–1.99)	0.006^a
	E2F4	337	1.50 (0.99–2.29)	0.055	896	1.16 (0.87–1.54)	0.305
	E2F5	337	1.00 (0.66–1.52)	0.985	896	1.27 (0.96–1.68)	0.099
	E2F6	337	0.65 (0.43–1.00)	0.046^a	896	0.68 (0.51–0.91)	0.009^a
	E2F7	172	0.85 (0.46–1.58)	0.613	162	1.90 (0.78–4.61)	0.149
	E2F8	337	1.31 (0.86–1.98)	0.207	896	2.01 (1.50–2.69)	<0.001^a

P<0.05. HR, hazard radio; CI, confidence interval; N/A, not available; ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor 2.