Figure 1.

Upregulation of SphK1 correlates with poor prognosis in HCC. qRT-PCR analysis of relative (A) SphK1 and (B) SphK2 expression levels in 21 HCC tissues and the adjacent non-tumors tissues. Data were normalized to the expression of 18S rRNA. Each sample was analyzed in triplicate. (C) Kaplan-Meier survival curve for HCC patients with high SphK1 expression (n=11) and low SphK1 mRNA expression (n=10). The survival data were compared using the log-rank test. SphK, Sphingosine kinase; HCC, hepatocellular carcinoma.