Table I.
Top 5 most significantly enriched GO terms for the 30 differentially expressed genes with the highest connectivity degree in the module ‘blue4’ in BP and CC, and all significantly enriched terms in MF.
| Category | ID | Term | P-value | Count | Genes |
|---|---|---|---|---|---|
| BP | GO:0007051 | Spindle organization | 0.000091 | 5 | UBE2C, SAC3D1, MYBL2, AURKB, NCOR1 |
| BP | GO:0051225 | Spindle assembly | 0.000131 | 4 | SAC3D1, MYBL2, AURKB, NCOR1 |
| BP | GO:0022402 | Cell cycle process | 0.000602 | 10 | CDKN3, UBE2C, SAC3D1, MCM6, MYBL2, KAT2B, AURKB, NOLC1, NCOR1, CDC20 |
| BP | GO:0000280 | Nuclear division | 0.001058 | 6 | UBE2C, SAC3D1, MYBL2, AURKB, NOLC1, CDC20 |
| BP | GO:0007067 | Mitosis | 0.001058 | 6 | UBE2C, SAC3D1, MYBL2, AURKB, NOLC1, CDC20 |
| MF | GO:0005515 | Protein binding | 0.004683 | 22 | CDKN3, GPNMB, ADRM1, UBE2C, LAMB3, MCM6, NELL2, PLAU, NDRG2, CDC20… |
| MF | GO:0005488 | Binding | 0.032021 | 26 | GNE, CDKN3, GPNMB, ADRM1, UBE2C, MCM6, NELL2, PLAU, NDRG2, CDC20… |
| CC | GO:0005680 | Anaphase-promoting complex | 0.013075 | 2 | UBE2C, CDC20 |
| CC | GO:0031974 | Membrane-enclosed lumen | 0.013075 | 12 | UBE2C, CRAT, CACYBP, HNRNPA2B1, MCM6, NUDT1, CCDC86, KAT2B, AURKB, CDC20… |
| CC | GO:0005819 | Spindle | 0.013075 | 4 | SAC3D1, AURKB, NCOR1, CDC20 |
| CC | GO:0000152 | Nuclear ubiquitin ligase complex | 0.013075 | 2 | UBE2C, CDC20 |
| CC | GO:0044427 | Chromosomal part | 0.018472 | 5 | MYBL2, KAT2B, AURKB, H2AFV, NCOR1 |
GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function.