Table I.
In vivo effect of OOS on gene expression profiles.
| Transcript cluster ID | Control Avg signal | OOS Avg signal | Fold change (C vs. OOS) | ANOVA p-value (C vs. OOS) | FDR p-value (C vs. OOS) | Gene symbol | Description |
|---|---|---|---|---|---|---|---|
| TC1200010961.hg.1 | 6.89 | 5.71 | 2.26 | 0.026035 | 0.698253 | NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 α subcomplex, 4-like 2 |
| TC2000007083.hg.1 | 4.89 | 3.75 | 2.2 | 0.00829 | 0.698253 | ID1 | Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| TC2100007394.hg.1 | 4.84 | 4.07 | 1.7 | 0.022428 | 0.698253 | ITGB2 | Memczak2013 ANTISENSE, CDS, coding, INTERNAL best transcript NM_001127491 |
| TC1000008663.hg.1 | 4.99 | 4.24 | 1.69 | 0.023254 | 0.698253 | SEMA4G | Sema domain (Dom), Ig Dom, transmembrane Dom and short cytoplasmic Dom; semaphorin 4G |
| TC1700012281.hg.1 | 5.62 | 4.88 | 1.68 | 0.028637 | 0.698253 | EPN3 | Epsin 3 |
| TC0200011898.hg.1 | 7.56 | 6.82 | 1.67 | 0.032135 | 0.698253 | SDC1 | Syndecan 1 |
| TC0100013266.hg.1 | 4.94 | 4.22 | 1.64 | 0.02815 | 0.698253 | C1orf234 | Chromosome 1 open reading frame 234 |
| TC0X00008694.hg.1 | 4.67 | 3.97 | 1.63 | 0.002167 | 0.698253 | HSFX1 | Heat shock transcription factor family, X-linked 1 |
| TC0300013665.hg.1 | 4.72 | 4.03 | 1.62 | 0.010431 | 0.698253 | MUC4 | Mucin 4, cell surface associated |
| TC0X00006567.hg.1 | 6 | 5.3 | 1.62 | 0.03384 | 0.698253 | VCX3B; VCX | Variable charge, X-linked 3B; variable charge, X-linked |
| TC0400006449.hg.1 | 6.39 | 5.7 | 1.61 | 0.033002 | 0.698253 | ZNF141 | Transcript Identified by AceView, Entrez Gene ID(s) 100288237; 7700 |
| TC0Y00007078.hg.1 | 5.99 | 5.31 | 1.6 | 0.038427 | 0.698253 | VCY; VCY1B | Variable charge, Y-linked; variable charge, Y-linked 1B |
| TC1700010088.hg.1 | 5.62 | 4.94 | 1.6 | 0.0348 | 0.698253 | NATD1 | N-acetyltransferase domain containing 1 |
| TC0100006755.hg.1 | 9.2 | 8.54 | 1.59 | 0.013559 | 0.698253 | ENO1 | Memczak2013 ANTISENSE, coding, INTERNAL, UTR3 best transcript NM_001428 |
| TC0100018271.hg.1 | 4.91 | 4.24 | 1.59 | 0.045745 | 0.698253 | OLFML3 | Olfactomedin like 3 |
| TC0X00006558.hg.1 | 6.93 | 6.26 | 1.59 | 0.017512 | 0.698253 | VCX; VCX3A | Variable charge, X-linked; variable charge, X-linked 3A |
| TC1100011257.hg.1 | 6.5 | 5.83 | 1.59 | 0.030276 | 0.698253 | EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 |
| TC1700009144.hg.1 | 6.03 | 5.37 | 1.58 | 0.043374 | 0.698253 | CHMP6 | Charged multivesicular body protein 6 |
| TC1200012664.hg.1 | 4.37 | 3.72 | 1.57 | 0.047618 | 0.698253 | MYRFL | Myelin regulatory factor-like |
| TC1900011334.hg.1 | 4.7 | 4.04 | 1.57 | 0.016798 | 0.698253 | ZNF677 | Zinc finger protein 677 |
| TC0600009871.hg.1 | 5.52 | 4.88 | 1.56 | 0.029687 | 0.698253 | ESR1 | Estrogen receptor 1 |
| TC1900008366.hg.1 | 6.17 | 5.55 | 1.54 | 0.038319 | 0.698253 | IGFL1 | IGF like family member 1 |
| TC1900011772.hg.1 | 6.53 | 5.91 | 1.54 | 0.015269 | 0.698253 | CRX | Cone-rod homeobox |
| TC0200010818.hg.1 | 6.34 | 5.73 | 1.53 | 0.016051 | 0.698253 | WNT10A | Wingless-type MMTV integration site family, member 10A |
| TC0800012281.hg.1 | 5.44 | 4.84 | 1.52 | 0.004602 | 0.698253 | C8orf58 | Chromosome 8 open reading frame 58 |
| TC1900008017.hg.1 | 6.5 | 5.89 | 1.52 | 0.03701 | 0.698253 | RYR1 | Ryanodine receptor 1 (skeletal) |
| TC0100012921.hg.1 | 7.49 | 6.9 | 1.51 | 0.027124 | 0.698253 | DHRS3; MIR6730 | Dehydrogenase/reductase (SDR family) member 3; microRNA 6730 |
| TC0X00010933.hg.1 | 6.1 | 5.51 | 1.51 | 0.017036 | 0.698253 | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| TC1900007020.hg.1 | 6.28 | 5.68 | 1.51 | 0.03582 | 0.698253 | ANGPTL8 | Angiopoietin like 8 |
| TC1900007384.hg.1 | 6.52 | 5.93 | 1.51 | 0.014667 | 0.698253 | GDF15 | Growth differentiation factor 15 |
| TC1900011656.hg.1 | 5.27 | 4.67 | 1.51 | 0.001409 | 0.698253 | STXBP2 | Syntaxin binding protein 2 |
| TC0300013151.hg.1 | 5.75 | 6.34 | −1.51 | 0.024943 | 0.698253 | NCEH1 | Neutral cholesterol ester hydrolase 1 |
| TC0300013264.hg.1 | 6.75 | 7.34 | −1.51 | 0.007192 | 0.698253 | GNB4 | Guanine nucleotide binding protein (G protein), β polypeptide 4 |
| TC1000007895.hg.1 | 5.36 | 5.96 | −1.51 | 0.047298 | 0.698253 | TSPAN15 | Tetraspanin 15 |
| TC1700011277.hg.1 | 5.68 | 6.27 | −1.51 | 0.005171 | 0.698253 | TRIM37 | Transcript Identified by AceView, Entrez Gene ID(s) 4591 |
| TC1200006454.hg.1 | 6.08 | 6.69 | −1.52 | 0.017021 | 0.698253 | WNK1 | Transcript Identified by AceView, Entrez Gene ID(s) 378465; 65125 |
| TC0600011507.hg.1 | 6.91 | 7.54 | −1.55 | 0.034697 | 0.698253 | PSMB8 | Proteasome subunit β8 |
| TSUnmapped00000243.hg.1 | 6.34 | 6.97 | −1.55 | 0.041704 | 0.698253 | MANSC1 | MANSC domain containing 1 |
| TC0100013902.hg.1 | 4.58 | 5.22 | −1.56 | 0.039592 | 0.698253 | SVBP | Small vasohibin binding protein |
| TC0500011513.hg.1 | 5.24 | 5.88 | −1.56 | 0.003247 | 0.698253 | PCSK1 | Proprotein convertase subtilisin/kexin type 1 |
| TC1900011312.hg.1 | 7.48 | 8.12 | −1.56 | 0.044255 | 0.698253 | ZNF611 | Zinc finger protein 611 |
| TC0300013520.hg.1 | 5.41 | 6.08 | −1.59 | 0.019529 | 0.698253 | CLDN1 | Claudin 1 |
| TC0100013223.hg.1 | 5.83 | 6.51 | −1.6 | 0.027675 | 0.698253 | RAP1GAP | RAP1 GTPase activating protein |
| TC0X00011080.hg.1 | 4.29 | 4.97 | −1.6 | 0.010211 | 0.698253 | MAGEA9; MAGEA9B | MAGE family member A9; MAGE family member A9B |
| TC0800011566.hg.1 | 5.2 | 5.89 | −1.61 | 0.041099 | 0.698253 | RAD21 | Transcript Identified by AceView, Entrez Gene ID(s) 5885 |
| TC1200011870.hg.1 | 5.78 | 6.47 | −1.61 | 0.030776 | 0.698253 | KCTD10 | Potassium channel tetramerization domain containing 10 |
| TC0500007145.hg.1 | 4.22 | 4.92 | −1.62 | 0.049614 | 0.698253 | SKP2 | Transcript Identified by AceView, Entrez Gene ID(s) 6502 |
| TC1200012736.hg.1 | 3.76 | 4.46 | −1.63 | 0.020998 | 0.698253 | ZNF10 | Zinc finger protein 10 |
| TC0400008450.hg.1 | 5.23 | 5.94 | −1.64 | 0.035161 | 0.698253 | ANK2 | Ankyrin 2, neuronal |
| TC1100006674.hg.1 | 4.4 | 5.13 | −1.65 | 0.037934 | 0.698253 | OR51T1 | Olfactory receptor, family 51, subfamily T, member 1 |
| TC1000009092.hg.1 | 4.64 | 5.38 | −1.66 | 0.028207 | 0.698253 | INPP5F | Inositol polyphosphate-5-phosphatase F |
| TC1800009244.hg.1 | 4.68 | 5.41 | −1.66 | 0.027752 | 0.698253 | HMSD | Histocompatibility (minor) serpin domain containing |
| TC0900009855.hg.1 | 4.81 | 5.56 | −1.69 | 0.015155 | 0.698253 | BAG1 | Bcl-2-associated athanogene |
| TC0500009304.hg.1 | 4.84 | 5.62 | −1.71 | 0.04978 | 0.698253 | GABRG2 | γ-aminobutyric acid (GABA) A receptor, γ 2 |
| TC1200010538.hg.1 | 5.22 | 6 | −1.72 | 0.037044 | 0.698253 | AMIGO2 | Adhesion molecule with Ig-like domain 2 |
| TC1400010625.hg.1 | 4.83 | 5.61 | −1.72 | 0.040343 | 0.698253 | ZNF410 | Zinc finger protein 410 |
| TC0400008972.hg.1 | 4.53 | 5.33 | −1.74 | 0.04379 | 0.698253 | DCLK2 | Doublecortin-like kinase 2 |
| TC0200013298.hg.1 | 5.03 | 5.86 | −1.78 | 0.045777 | 0.698253 | ST3GAL5 | ST3 β-galactoside α-2.3-sialyltransferase 5 |
| TC1200009590.hg.1 | 4.5 | 5.34 | −1.79 | 0.011405 | 0.698253 | DCP1B | Decapping mRNA 1B |
| TC1400007201.hg.1 | 6.39 | 7.23 | −1.79 | 0.02332 | 0.698253 | CDKN3 | Cyclin-dependent kinase inhibitor 3 |
| TC1500007644.hg.1 | 4.13 | 4.98 | −1.79 | 0.018087 | 0.698253 | C15orf61 | Chromosome 15 open reading frame 61 |
| TC0600008471.hg.1 | 5.3 | 6.16 | −1.81 | 0.011906 | 0.698253 | SDHAF4 | Succinate dehydrogenase complex assembly factor 4 |
| TC0700011796.hg.1 | 5.17 | 6.06 | −1.86 | 0.037538 | 0.698253 | SAMD9 | Sterile α motif domain containing 9 |
| TC0600009019.hg.1 | 4.77 | 5.68 | −1.87 | 0.00006 | 0.429919 | SOBP | Sine oculis binding protein homolog |
| TC0400012945.hg.1 | 5.78 | 6.7 | −1.9 | 0.045226 | 0.698253 | HSD17B11 | Hydroxysteroid (17-β) dehydrogenase 11 |
| TC0100008026.hg.1 | 5.32 | 6.4 | −2.12 | 0.021804 | 0.698253 | YBX1 | Zhang2013 ALT_ACCEPTOR, ALT_DONOR, coding, INTERNAL, intronic best transcript |
| TC1100006671.hg.1 | 5.76 | 6.88 | −2.17 | 0.021524 | 0.698253 | OR51F2 | Olfactory receptor, family 51, subfamily F, member 2 |
| TC0900009779.hg.1 | 5.16 | 6.3 | −2.19 | 0.030103 | 0.698253 | C9orf72 | Chromosome 9 open reading frame 72 |
Comparison of the gene expression profiles of three control tumors to that of three OOS treated ones. Table shows those genes whose expression changed >1.5 times in that analysis (fold change C vs. OOS). OOS, Ocoxin® oral solution.