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. 2018 Apr 13;15(6):4749–4754. doi: 10.3892/etm.2018.6069

Figure 2.

Figure 2.

Comparison of the relative APOE methylation between ASD cases and healthy controls. (A) Comparison between ASD cases and controls. The median PMR in cases and controls was 33% (interquartile range, 25 and 37%) and 11% (interquartile range, 6 and 23%), respectively. The P-value for the comparison between the cases and the controls was 2.36×10−10. (B) Comparison between male ASD cases and male controls. The median PMR values of cases and controls were 32% (23, 37%) and 11% (6, 27%), respectively. The P-value for the comparison between the male cases and the male controls was 8.52×10−10. (C) Comparison between female ASD cases and female controls. The median PMR values of cases and controls were 0.42 (0.29, 0.56) and 0.08 (0.05, 0.10), respectively. The P-value for the comparison between the female cases and the female controls was 4.18×10−6. APOE, apolipoprotein E; ASD, autism spectrum disorder; PMR, percentage of methylation of a reference.