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. 2018 Apr 13;8(6):719–724. doi: 10.3892/mco.2018.1608

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Copyright: © Horbach et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Protein interaction network of genes involved in resistance to chemotherapy. Genes selected for this study are represented in red or green according to higher or lower relative mRNA expression, respectively, between control and chemoresistant Ewing sarcoma cells. DNA-topoisomerase (TOP)2A and TOP2B (pink/orange) were included due to their role as doxorubicin targets. Genes involved in spliceosomal activity and EWS/FLI1 activity are shown in yellow. The network was constructed using the STRING database, version 10.5.