Table II.
Hub genes of the PPI network with higher node degrees.
| Hub gene | Gene name | Node degree |
|---|---|---|
| Upregulated | ||
| MMP9 | Matrix metallopeptidase 9 | 15 |
| APOE | Apolipoprotein E | 10 |
| CCNE1 | Cyclin E1 | 8 |
| SDC1 | Syndecan 1 | 7 |
| FOXM1 | Forkhead box M1 | 7 |
| TYMS | Thymidylate synthetase | 6 |
| MYBL2 | MYB proto-oncogene like 2 | 6 |
| Downregulated | ||
| ESR1 | Estrogen receptor 1 | 14 |
| CXCL12 | C-X-C motif chemokine ligand 12 | 10 |
| AR | Androgen receptor | 10 |
| WT | Wilms tumor 1 | 9 |
| IGF1 | Insulin like growth factor 1 | 8 |
| THBS1 | Thrombospondin 1 | 7 |
| FOXO1 | Forkhead box O1 | 6 |
| PTGER3 | Prostaglandin E receptor 3 | 6 |
| CD34 | Cluster of differentiation | 6 |
| 34 molecule |
PPI, protein-protein interaction.