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There are KRAS-mutant lung adenocarcinomas expressing thyroid transcription factor 1 (TTF-1). (A) Immunohistochemistry for TTF-1 expression in KRAS-mutant lung adenocarcinoma samples from two patients. The tumor cells of invasive mucinous adenocarcinoma (patient 26) were completely negative for TTF-1. Scale bars, 100 μm. (B) Representative western blots of untreated H358 and H441 cells. Both cell lines were positive for TTF-1.
