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. 2018 Apr 11;15(6):9142–9150. doi: 10.3892/ol.2018.8463

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Neutralizing IL-6 attenuates the action of BC-MSCs on inhibition of MCF-7 cells induced by cisplatin. (A) IL-6-neutralization antibody recovered cisplatin-induced apoptosis in MCF-7 cells incubated with BC-MSC-CM. **P<0.01, compared with the cisplatin group; ^#P<0.05, compared with the BC-MSC-CM group. (B) IL-6 neutralization antibody decreased the MCF-7 cell vitality. *P<0.05, compared with the cisplatin group; ^#P<0.05, compared with the BC-MSC-CM group. (C) Western blot analysis of protein levels of Bax, STAT3, p-STAT3, IL-6 in MCF-7 cells in response to the indicated treatment. IL-6, interleukin-6; BC-MSC, breast-cancer-derived mesenchymal-stem-cell-conditioned medium; p-STAT3, phosphorylated signal transducer and activator of transcription 3; Bax, B-cell lymphoma-associated X.