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. 2018 Mar 27;53(1):59–72. doi: 10.3892/ijo.2018.4333

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Copyright: © Pan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Dyregulation of MORC2 disrupts several crucial cancer-related pathways. (A) Knockdown of MORC2 activates apoptotic pathways. (B) Based on the Kyoto Encyclopedia of Genes and Genomes database, gene expression profile analysis identified significant different pathways modulated by MORC2. (C) In HepG2 cells, knockdown of MORC2 activated the p53 pathway. (D) In HepG2 cells, knockdown of MORC2 inhibited the Hippo pathway. MORC2, microrchidia; PARP, poly (ADP-ribose) polymerase; Bcl-2, B-cell lymphoma-2; Bax, Bcl-2-associated X protein; PUMAα, p53 upregulated modulator of apoptosis α; p-, phosphorylated; si, small interfering RNA; NC, negative control; YAP1, Yes-associated protein 1; TAZ, transcriptional co-activator with PDZ-binding motif.