Table 4.
Parameter | Description | Value |
---|---|---|
VC | Cell volume (fL cell−1) | 520 |
F | Interstitial Fraction | 0.48 |
DS | Drug diffusivity (μm2 min−1) | 30E3 |
k1 | Plasma elimination rate (min−1) | 2.77E-2 |
k12 | Drug uptake (min−1) | 0.054 |
k21 | Drug efflux (min−1) | 1.56E-3 |
k23 | Drug-DNA binding (min−1) | 3.82E-4 |
k32 | Drug-DNA release (min−1) | 0 |
k3 | Drug-DNA repair (min−1) | 0.015 |
k24 | Lysosomal sequestration (min−1) | 0 |
k42 | Lysosomal release (min−1) | 0 |
sm | Drug-DNA capacity (fmole) | ∞ |