. Author manuscript; available in PMC: 2019 Jul 7.

Published in final edited form as: J Theor Biol. 2018 Apr 1;448:38–52. doi: 10.1016/j.jtbi.2018.03.035

Table 4.

Pharmacokinetic parameters for CDDP (from (Sinek et al., 2009) and associated references).

Parameter	Description	Value
V_C	Cell volume (fL cell⁻¹)	520
F	Interstitial Fraction	0.48
D_S	Drug diffusivity (μm² min⁻¹)	30E3
k₁	Plasma elimination rate (min⁻¹)	2.77E-2
k₁₂	Drug uptake (min⁻¹)	0.054
k₂₁	Drug efflux (min⁻¹)	1.56E-3
k₂₃	Drug-DNA binding (min⁻¹)	3.82E-4
k₃₂	Drug-DNA release (min⁻¹)	0
k₃	Drug-DNA repair (min⁻¹)	0.015
k₂₄	Lysosomal sequestration (min⁻¹)	0
k₄₂	Lysosomal release (min⁻¹)	0
s_m	Drug-DNA capacity (fmole)	∞