Table 5.

Pharmacokinetic parameters for dFdC (from (Battaglia Jr. and Parker, 2011) and associated references).

Parameter	Description	Value
VC	Cell volume (fL cell−1) (a)	520
F	Interstitial Fraction (a)	0.48
DS	Drug diffusivity (μm2 min−1) (a)	30E3
k1	Plasma elimination rate (min−1)	1.16E-2
V12	Drug uptake (μM min−1)	55.7
K12	Half-maximum transport conc. (μM)	5.2
k21	Drug efflux (min−1)	0
k2	Inactivation rate (min−1)	1.7
V2a	Activation rate (μM min−1)	7.7
K2a	Half maximum activation conc. (μM)	2.5
k2a3	Drug-DNA binding (min−1)	5.7E-3
k32	Drug-DNA release (min−1)	0
k3	Drug-DNA repair (min−1)	0
k24	Lysosomal sequestration (min−1)	0
k42	Lysosomal release (min−1)	0
sm	Drug-DNA capacity (fmole)	∞

^(a)Assumed consistent with cisplatin (from (Sinek et al., 2009)).