. Author manuscript; available in PMC: 2019 Jul 7.

Published in final edited form as: J Theor Biol. 2018 Apr 1;448:38–52. doi: 10.1016/j.jtbi.2018.03.035

Table 8.

Sensitivity of the tumor net proliferation rate λ_p on the CDDP pharmacokinetic parameters.

Parameter	Description	λ_p perturbed /λ_p unperturbed
Parameter	Description	Parameter x 10	Parameter / 10
k₁	Plasma elimination rate (min⁻¹)	0.93	1.02
k₁₂	Drug uptake (min⁻¹)	1.04	0.92
k₂₁	Drug efflux (min⁻¹)	0.98	1.00
k₂₃	Drug-DNA binding (min⁻¹)	1.87	0.90
k₃₂	Drug-DNA release (min⁻¹)	(*)	(*)
k₃	Drug-DNA repair (min⁻¹)	0.91	1.06
k₂₄	Lysosomal sequestration (min⁻¹)	(*)	(*)
k₄₂	Lysosomal release (min⁻¹)	(*)	(*)

(*) Parameter unperturbed value was 0 (Table 4).