Table 9.

Sensitivity of the tumor net proliferation rate λ_p on the dFdC pharmacokinetic parameters.

Parameter	Description	λp perturbed /λp unperturbed
		Parameter x 10	Parameter / 10
k1	Plasma elimination rate (min−1)	1.00	1.00
V12	Drug uptake (μM min−1)	1.01	0.44
K12	Half-maximum transport conc. (μM)	0.97	1.01
k21	Drug efflux (min−1)	(*)	(*)
k2	Inactivation rate (min−1)	0.58	1.08
V2a	Activation rate (μM min−1)	5.86	0.14
K2a	Half maximum activation conc. (μM)	0.57	1.10
k2a3	Drug-DNA binding (min−1)	6.25	0.14
k32	Drug-DNA release (min−1)	(*)	(*)
k3	Drug-DNA repair (min−1)	(*)	(*)
k24	Lysosomal sequestration (min−1)	(*)	(*)
k42	Lysosomal release (min−1)	(*)	(*)

(*) Parameter unperturbed value was 0 (Table 5).