Figure 1. Anticatalase-Lentiviral vector administration into the ventral tegmental area reduces voluntary alcohol intake in alcohol-naïve UChB rats.
Alcohol-naïve UChB rats significantly [ANOVA; F (1,117) = 221.23, P < 0.001] reduced their alcohol intake when injected a lentiviral vector coding for a shRNA against catalase (Anticatalase-Lenti) into the VTA, compared to alcohol-naïve rats that received an injection of an empty lentiviral vector (control-Lenti). Animals were allowed free availability of 10% (v/v) ethanol and water four days after the administration a single dose (8×104 virus) of anticatalase-Lenti-shRNA vector (n=12) or an empty lentiviral vector (control-Lenti) (n=12). See Experiment 1 in Methods. Abscissa: days of ethanol availability. Data shown are means± S.E.M.