Table 4.
Dosages of most frequently used drugs for the treatment of gastroesophageal reflux disease
| Drugs | Recommended pediatric dosages | Maximum dosages (based upon adult dosage) |
|---|---|---|
| Histamine-2 Receptor Antagonists (H2RAs) | ||
| - Ranitidine | 5–10 mg/kg/day | 300 mg |
| - Cimetidine | 30–40 mg/kg/day | 800 mg |
| - Nizatidine | 10–20 mg/kg/day | 300 mg |
| - Famotidine | 1 mg/kg/day | 40 mg |
| Proton Pump Inhibitors (PPIs) | ||
| - Omeprazole | 1–4 mg/kg/day | 40 mg |
| - Lansoprazole | 2 mg/kg/day for infants | 30 mg |
| - Esomeprazole | 10 mg/day (weight <20kg) or 20 mg/day (weight >20kg) | 40 mg |
| - Pantoprazole | 1–2 mg/kg/day | 40 mg |
| Prokinetics | ||
| - Metoclopramide | 0.4–0.9 mg/kg/day | 60 mg |
| - Domperidone | 0.8–0.9 mg/kg/day | 30 mg |
| - Baclofen | 0.5 mg/kg/day | 80 mg |
| Antacids | ||
| - Mg alginate plus simethicone | 2.5 ml 3×/day (weight < 5kg) or 5 ml 3×/day (weight >5 kg) | NA |
| - Sodium alginate | 225 mg sodium alginate and magnesium alginate 87.5 mg) in a total 0.65 g One sachet/day (weight <4.54 kg) or Two sachet/day (weight >4.54 kg) | NA |
NA; no data available