Figure 2.

The structures of three important amino acid-based therapeutics approved by the FDA.

Notes: (A) Aldesleukin (PDB ID: 1M47), a recombinant lymphokine, has been used for treatment of adults with metastatic renal cell carcinoma. (B) Leuprolide (PDB ID: 1YY2) is a synthetic nine-residue peptide analog of gonadotropin releasing hormone used to treat advanced prostate cancer. (C) Spaglumic acid (PubChem ID: 188803), a peptidomimetic, is used in allergic conditions such as allergic conjunctivitis. The structures of the drugs were visualized via PyMol.

Abbreviations: FDA, US Food and Drug Administration; PDB, Protein Data Bank.