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. Author manuscript; available in PMC: 2018 Aug 20.
Published in final edited form as: ACS Chem Biol. 2018 Feb 15;13(7):1767–1784. doi: 10.1021/acschembio.7b01029

Figure 1.

Figure 1

Schematic representation of an integrated microphysiological system. Multiple interconnected organotypic microtissue models can be co-cultured in the platform to enable tissue-to-tissue interactions. The pumping and related flow mimics physiological shear stress on the tissues. The integrated sensors and actuators enable in situ monitoring, characterization and manipulation of the tissue models and of potentially circulating cells.