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. Author manuscript; available in PMC: 2018 May 18.
Published in final edited form as: Adv Biosyst. 2018 Apr 2;2(5):1700221. doi: 10.1002/adbi.201700221

Figure 10.

Figure 10

A–C) Schematic of considerations for the design of “organ-on-a-chip” microfluidic platforms. The in vivo TME is complex, but aspects such as vasculature, ECM components, and lymph fluid flow can be incorporated into an in vitro microfluidic scheme for the study of cancer cell behavior. In vitro models of vascular flow are imperative to understanding how cancer cells move through endothelial junctions into blood vessels or into lymph nodes. Adapted with permission.[145] Copyright 2011, National Academy of Sciences. Adapted with permission.[146] Copyright 2015, Elsevier.