Table 1.
Retinal ganglion cell density in superior, inferior, nasal and temporal retinal quadrants in animals treated with celastrol or vehicle. Data presented as mean ± SD.
| Animal Group |
Distance from ONH |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Inferior |
Nasal |
Superior |
Temporal |
|||||||||||||
| 1 mm | 2 mm | 3 mm | 4 mm | 1 mm | 2 mm | 3 mm | 4 mm | 1 mm | 2 mm | 3 mm | 4 mm | 1 mm | 2 mm | 3 mm | 4 mm | |
| Vehicle | 2204.5 ± 369.4 | 2237.2 ± 281.3 | 1665.8 ± 174.5 | 1014.6 ± 145.1 | 2246.3 ± 311.5 | 2116.9 ± 324.3 | 1875.0 ± 216.6 | 1474.9± 233.7 | 2330.0 ± 276.1 | 1712.9 ± 335.8 | 1248.7 ± 450.0 | 889.1 ± 355.8 | 2247.6 ± 315.3 | 2387.6 ± 324.4 | 2314.3 ± 269.4 | 1410.8 ± 193.5 |
| Celastrol | 2246.2 ± 209.2 | 2076.2 ± 254.6 | 1606.4 ± 293.6 | 1006.8 ± 273.5 | 2353.6 ± 135.9 | 2282.6 ± 195.0 | 2065.0 ± 201.2 | 1509.3 ± 265.8 | 2595.4 ± 245.4 | 2341.4 ± 511.3 | 1367.3 ± 351.0 | 933.0 ± 284.8 | 2455.4 ± 287.3 | 2412.4 ± 281.7 | 2381.6 ± 304.3 | 1550.4 ± 390.0 |
| Vehicle/IOP | 1950.8 ± 166.2 | 1736.4 ± 239.2 | 1375.5 ± 244.8 | 826.4 ± 134.3 | 1987.4 ± 483.4 | 1965.2 ± 655.3 | 1701.1± 595.2 | 1216.0 ± 459.7 | 1354.6 ± 1021.4 | 1417.4 ± 949.3 | 1036.9 ± 745.7 | 538.7 ± 370.3 | 1400.4 ± 958.2 | 1503.7 ± 973.5 | 1480.1 ± 981.1 | 1070.9 ± 748.8 |
| Celastrol/IOP | 2195.7 ± 223.3 | 2017.3 ± 266.4 | 1631.6 ± 377.5 | 1027.3 ± 372.3 | 2209.7 ± 256.3 | 2190.1 ± 257.4 | 2036.9 ± 256.8 | 1448.6 ± 295.4 | 1786.6 ± 893.1 | 1978.1 ± 774.3 | 1451.4 ± 618.4 | 887.3 ± 496.3 | 1886.6 ± 934.2 | 2035.1 ± 968.3 | 1919.3 ± 894.4 | 1264.6 ± 668.9 |