Table 2. Genes significantly repressed (>2.0-fold and p<0.05) at 7 or 18h during the formation of titan-like cells.

Functional assignments were based on Gene Ontology. For unassigned genes, additional Blastp comparisons against fungal data bases were carried out. T: Titan-like cells (cells incubated in TCM at 10⁴ cells/mL); S (cells of regular size, incubated in TCM at 10⁶ cells/mL).

			7 h		18 h
Process	Gene ID	Description	T/S ratio	p-val.	T/S ratio	p-val.
DNA Replication adn DNA Repair (p-value: 1.3E-03)
	CNAG_00680	kinetochore protein Nuf2, variant	0.1	3.6E-04	0.4	6.9E-03
	CNAG_00681	condensin complex subunit 3, variant	0.2	6.7E-03	0.6
	CNAG_00991	flap endonuclease 1	0.1	2.4E-03	0.7
	CNAG_01144	replication factor A1	0.3	4.1E-02	0.8
	CNAG_01430	hypothetical protein	0.1	2.8E-03	0.6
	CNAG_01916	DNA mismatch repair protein Msh6	0.3	4.8E-02	0.6
	CNAG_01959	condensin complex subunit 1	0.2	1.3E-02	0.4	6.6E-03
	CNAG_02491	nuclear protein	0.1	3.4E-02	0.2	2.4E-03
	CNAG_02884	DNA replication complex GINS protein Psf2	0.2	2.8E-02	0.7
	CNAG_02963	anaphase-promoting complex subunit 8	0.1	2.6E-02	0.4
	CNAG_03148	nuclear condensin complex protein	0.2	2.5E-02	0.5	4.6E-02
	CNAG_04231	hypothetical protein	0.2	3.9E-02	0.5
	CNAG_04682	DNA replication complex GINS protein Psf3	0.1	6.5E-04	0.2	4.5E-03
	CNAG_05177	DNA polymerase kappa subunit	0.1	6.0E-04	0.3	3.4E-03
	CNAG_05468	AP endonuclease 1	0.2	3.2E-02	0.4
	CNAG_05891	TDG/mug DNA glycosylase	0.2	2.9E-02	0.8
	CNAG_06273	hypothetical protein	0.2	2.8E-02	0.5
	CNAG_06588	hypothetical protein, variant	0.2	3.9E-02	0.5
	CNAG_06634	DNA polymerase epsilon subunit B	0.2	1.5E-02	0.5
	CNAG_06793	exonuclease 1	0.2	2.6E-02	0.6
	CNAG_07657	U3 small nucleolar RNA-associated protein 19	0.2	4.6E-02	0.5
Ribosome biogenesis (p-value: 1.1E-03)
	CNAG_01104	ribosomal RNA-processing protein 8 (RRP8)	0.2	7.3E-04	0.5
	CNAG_01550	pre-rRNA-processing protein (TSR3)	0.1	6.1E-04	0.5
	CNAG_01715	ribosome biogenesis protein (BMS1)	0.2	1.2E-02	0.7
	CNAG_01812	large subunit ribosomal protein L24e	0.2	4.8E-02	0.4
	CNAG_02672	nonsense-mediated mRNA decay 3 (NMD3)	0.2	2.5E-02	0.5
	CNAG_03724	ribosomal RNA methyltransferase Nop2	0.3	3.3E-02	0.5
	CNAG_03954	ribosomal RNA-processing protein 17	0.2	1.9E-02	0.4
	CNAG_04259	H/ACA ribonucleoprotein complex subunit 1	0.2	4.5E-02	1.0
Transmembrane transport (p-value: 4.8E-6)
	CNAG_00726	Allantoate permease (DAL5)	0.0		0.0	3.4E-02
	CNAG_00898	multidrug efflux pump, YOR378W-related	0.1		0.0	4.9E-03
	CNAG_00904	aflatoxin efflux pump Aflt	0.1		0.0	7.5E-03
	CNAG_01118	putative dicarboxylic amino acid permease	0.1	1.0E-03	0.2	4.2E-02
	CNAG_01545	hypothetical protein, variant	0.2		0.3	3.3E-02
	CNAG_01862	hexose transporter (STL1, HXT8, HXT13,. family)	0.3		0.2	4.7E-02
	CNAG_02595	hypothetical protein, variant	0.1	2.7E-02	0.2	1.5E-02
	CNAG_02733	hexose transporter (STL1, HXT8, HXT13,. family)	0.3		0.0	6.9E-03
	CNAG_02777	Pi transporter PHO84	0.4		0.5	1.4E-02
	CNAG_04567	putative TPO-related spermine transporter	0.2		0.3	2.8E-02
	CNAG_04597	hypothetical protein	0.2		0.3	1.8E-02
	CNAG_04784	Sugar transporter (STL1, SNF3 family)	0.1		0.2	3.3E-02
	CNAG_04794	spermine transporter (TPO2, TPO3 family)	0.2	5.3E-04	0.5	4.4E-02
	CNAG_04818	MFS monocarboxylate transporter, putative	0.1	2.2E-02	0.2	2.4E-02
	CNAG_05662	hexose transporter (HXT8, HXT13, HXT17 family)	0.1	1.2E-02	0.3	2.2E-02
	CNAG_05867	L-fucose permease, putative	0.2		0.2	1.1E-05
	CNAG_05992	Allantoate permease	0.1		0.0	1.9E-02
	CNAG_06102	ADP,ATP carrier protein, variant 1	0.1	6.6E-05	0.2	7.5E-03
	CNAG_06292	sugar transporter	0.1		0.2	2.5E-02
	CNAG_06557	N-acetylglucosamine-specific transporter	0.6		0.0	3.2E-03
	CNAG_06561	allantoate transporter	0.0		0.0	2.6E-02
	CNAG_06758	multidrug efflux pump, YOR378W-related	0.3		0.2	2.9E-04
	CNAG_06932	sugar transporter (STL1, HXT17, HXT13 family)	0.2		0.2	6.7E-03
	CNAG_07449	General amino acid permease (AGP2)	0.1		0.2	2.8E-02