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. 2018 Apr 1;32(7-8):512–523. doi: 10.1101/gad.312157.118

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© 2018 Cimino et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — HoxA5 overexpression in mouse glioblastomas leads to decreased survival, reflective of human disease. (A) Schematic of RCAS vectors used for mouse glioblastoma production. (B) Strategy for RCAS vector coinjections in mice with background containing either homozygous or heterozygous loss of Ink4a/Arf. (C) Expression of tagged HoxA5 or mCherry in mouse PDGF-driven glioblastoma lysate as confirmed by Western blot. HoxA5-overexpressing mouse glioblastomas had decreased survival in mice with homozygous (D) or heterozygous (E) loss of Ink4a/Arf, with both having decreased median survival (log-rank test; F).