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. 2018 Apr 1;32(7-8):512–523. doi: 10.1101/gad.312157.118

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© 2018 Cimino et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — HoxA5 expression is enriched in mouse and human recurrent glioblastomas. (A) Post-radiation recurrent mouse PDGF-driven glioblastomas have approximately fivefold increased HoxA5 mRNA compared with primary glioblastomas. (B) Immunohistochemical quantification determines that Myc-tagged HoxA5, but not Myc-tagged mCherry, represents increased percentage of RCAS-infected cells in post-radiation recurrent mouse glioblastomas. (C) HOXA5 expression in recurrent human IDH wild-type glioblastomas is highest in the proneural (PN) transcriptional subtype (n = 19) compared with mesenchymal (MES; n = 22), classical (CL; n = 14), and neural (NEU; n = 19). (D) Recurrent human IDH wild-type glioblastomas exhibit HOXA5 mRNA enrichment in proneural and classical transcriptional subtypes compared with their matched primary tumors.