FIGURE 2.

A second, independent set of psoriatic RNA-seq data show a decrease of editing in psoriatic lesions. (A) Total RNA-seq data set analysis repeats the trend of a decrease in the number of hyperediting sites in psoriatic lesions. Interestingly, after 1 mo of treatment with adalimumab, the editing levels restored back to a similar level of healthy control samples. The figure shows the distribution of the normalized number of hyperediting sites. P-value = 0.008, two-tailed t-test. (B) Healthy control and treated with adalimumab after 1-mo groups were joined together in order to achieve a better statistical power. Complementary hyperediting screening reveals a decrease in the number of editing sites in psoriatic lesions. P-value = 0.0004, two-tailed t-test. (C) Matched comparison of hyperediting in a sample between before and after treatment. P-value = 0.004, two-tailed t-test.