FIGURE 4.

Editing of conserved sites is reduced in psoriatic lesions. (A) The editing index of the conserved sites displays a lower signal in psoriatic lesions compared to uninvolved skin and healthy control samples. (B) Significantly decreased editing in conserved sites in psoriatic lesions. The editing activity in the sites that exhibit higher editing leads to nonsynonymous mutations in the COPA, FLNA, and IGFBP7 proteins. (C) IGFBP7 expression distribution in psoriatic lesions, uninvolved skin and healthy control samples. Down-regulation of IGFBP7 in psoriatic lesions as previously reported in the literature emphasizes the significant involvement of the gene in the pathology of psoriasis.