Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun;24(6):865–879. doi: 10.1261/rna.063206.117

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Hönig et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

FIGURE 1. — Schematic illustration of the antimiR administration protocol. (A) An antimiR directed against miR-29a-3p (or a scrambled antimiR) was administered by injection (○) via the intraperitoneal (i.p.) route (25 mg kg⁻¹) on the day of birth [postnatal day (P)1; ⋆] to newborn pups; or via either the i.p. (25 mg kg⁻¹) or intravenous (i.v.; 25 or 100 mg kg⁻¹) routes to pregnant dams on the 17th day of gestation, here denoted embryonic day (E)17. Organs were harvested (→|) on P1, P7, or P14. (B) The antimiR-29a-3p sequence corresponded to part of the seed sequence (contained within the dashed-line box) of the miR-29 family of microRNA, and as such, targeted all three miR-29 family members in mice: miR-29a-3p, miR-29b-3p, and miR-29c-3p. Nucleotide base mismatches comparing the three miR-29a family members are indicated with hollow letters. (hsa) Homo sapiens; (mmu) Mus musculus; (rno) Rattus norvegicus.