Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 30;29(8):661–677. doi: 10.1097/WNR.0000000000001015

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

PMC Copyright notice

Fig. 4 — Curcumin strengthened the UPR process to overcome ER stress after DAI by the nuclear translocation of Nrf2. (a) The expression levels of p-PERK, ATF4, and CHOP were measured by western blotting in each group. The expression of β-actin was used as an internal control. (b) The bar graphs show the results for p-PERK, ATF4, and CHOP expression, as assessed by western blotting in each group. Values are presented as the mean±SD (n=4; *P<0.05, compared with the control group; ^#P<0.05, compared with the DAI+vehicle group). (c) Double immunofluorescence staining was performed with an antibody against Nrf2 and another against p-PERK in each group. Scale bar=100 μm. (d) Double immunofluorescence staining was performed with an antibody against CHOP and another against ATF4 in each group. Scale bar=100 μm. (e) The bar graphs show the results for the numbers of p-PERK/Nrf2 copositive cells in each group. Values are presented as the mean±SD (n=4; *P<0.05, compared with the control group; ^#P<0.05, compared with the DAI+vehicle group). The bar graphs show the results for the numbers of CHOP/ATF4 copositive cells in each group. Values are presented as the mean±SD (n=4; *P<0.05, compared with the control group; ^#P<0.05, compared with the DAI+vehicle group). CUR, curcumin; DAI, diffuse axonal injury.