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Effect of AstD (11) and other AstB analogues on ip CRF-induced stimulation of defecation (A) and occurrence of diarrhea (B). Rats were injected sc with vehicle, AstD (11), 8, 13, 15, and 17 (200 μg/kg) and 12 h later ip with saline or CRF (10 μg/kg). The defecation and diarrhea were monitored for 1 h after the ip injection. Each column is the mean ± SEM of number of rats indicated: (*) p < 0.05 vs Veh-Veh and (#) p < 0.05 vs Veh-CRF. Veh = vehicle.
