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. Author manuscript; available in PMC: 2018 May 18.
Published in final edited form as: J Med Chem. 2016 Feb 3;59(3):854–866. doi: 10.1021/acs.jmedchem.5b00926

Figure 8.

Figure 8

Antagonistic action of AstB (1) and AstC (2) injected sc against the ip hUcn 2-induced delay of gastric emptying in rats. Overnight fasted rats were injected sc with vehicle (◆), AstB (■), or AstC (▲) (200 μg/kg) and 12 h later injected ip with vehicle or hUcn 2 (30 μg/kg). Ten minutes later, rats received an oral gavage with acetaminophen in 1.5% methylcellulose and blood was collected at 20, 40, and 60 min to assess gastric emptying. Data are the mean ± of five rats in each group: (*) p < 0.05 vs veh + hUcn 2.