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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Pathol. 2018 Apr 3;245(2):147–152. doi: 10.1002/path.5069

Figure 2.

Figure 2

E2 promotes ERα − CxCa in K14E7/Esr1ed/ed mice. (A) Cervical sections of CxCa arising in K14E7/Esr1ed/ed mice stained for ERα (green). An Esr1−/− tissue section was used as negative control. Dotted lines separate stroma (st) from normal epithelium (ep), dysplastic epithelium (CIN), and cancer epithelium (cc). (B) PR staining (green). A Pgr−/− tissue section was used as negative control. (C) Representative H&E staining. Note that the nondiseased epithelia in K14E7/Esr1ed/ed mice were hypoplastic (inset). (D) K10 staining (green). In (A), (B) and (D), nuclei were stained with Hoechst 33258 (pseoudocolored red). Scale bar = 50 μm.