Table 1.
Summary of Worst Neoplastic Diseases in the Cervix¶
| Genotypes | Group size, n | No disease | Dysplasia only | Cancer & dysplasia | Incidence(%) | Multiplicity$ | Largest Cancer Size (mm2)$ | Total Invasion Area (mm2)$ | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| CIN1 | CIN2 | CIN3 | ||||||||
| NTG/Esr1f/f | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| NTG/Esr1ed/ed | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| K14E7/Esr1f/f | 14 | 0 | 0 | 1 | 2 | 11 | 78.6 | 2.79 ± 0.71 | 0.09 ± 0.03 | 0.17 ± 0.06 |
| K14E7/Esr1ed/ed | 13 | 0 | 1 | 4 | 4 | 4 | 30.8* | 0.38 ± 0.18** | 0.03 ± 0.02** | 0.04 ± 0.02** |
¶
Mice were scored histopathologically for the worst disease present in the cervix of each mouse.
$
Mice without cancer are given ‘0’ and data is shown as mean ± SEM.
*
P = 0.02 compared to K14E7/Esr1f/f (Fisher’s exact test).
**
P < 0.02 compared to K14E7/Esr1f/f (Wilcoxon rank sum test).