Figure 2.

Effect of individual excipients on IPV3 relative potency losses after drying and storage of tIPV samples for 7 days at 4°C. Each condition is shown as a relative percentage D-antigen potency loss to a liquid tIPV stock solution (0% potency loss), and the black and gray bars denote D-antigen potency loss during drying and storage on LCP discs, respectively. Error bars represent the SD (1 SD) from quadruplicate experiments. Excipient samples were prepared in a M199/DPBS base buffer (see Materials and Methods section). Relative D-antigen potency stability values for IPV1, IPV2 and IPV3, and statistical analysis are shown in Supplemental Table S1.