Figure 3.

Concentration-dependent stabilization effect of individual excipients on IPV3 relative potency in tIPV samples after drying and storage for 7 days at 4°C. Each condition is shown as a relative percentage D-antigen potency loss compared with a liquid tIPV stock solution (0% potency loss), and the black and gray bars denote potency loss during drying and storage on LCP discs, respectively. Excipient samples were prepared in a M199/DPBS base buffer (see Materials and Methods section). Error bars represent the SD (1 SD) from triplicate experiments. Relative D-antigen potency loss values for IPV1, IPV2, and IPV3 are shown in Supplemental Tables S2-S4.