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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Clin Cancer Res. 2017 Aug 18;23(21):6629–6639. doi: 10.1158/1078-0432.CCR-17-0668

Figure 3.

Figure 3

The combination temsirolimus and RG7388 strongly inhibits neuroblastoma tumor growth. A, LAN5 MYCN-amplified xenografts were treated with vehicle, single-agent temsirolimus (10 mg/kg), single agent RG7388 (25 mg/kg), and their combination. Average tumor weights for each cohort ± SEM are shown (n = 10 in each group). Tumors treated with dual therapy are significantly smaller than those treated with single therapy. B, SH-SY5Y MYCN nonamplified xenografts received treatment as described above (A; n = 10 in each group). Tumors treated with dual therapy are significantly smaller than those treated with single therapies.