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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Clin Cancer Res. 2017 Aug 18;23(21):6629–6639. doi: 10.1158/1078-0432.CCR-17-0668

Figure 7.

Figure 7

Survivin overexpression rescues cell apoptosis induced by the dual therapy. A, Conditional survivin overexpression was confirmed in IMR32 cells after 48-hour induction with doxycycline by qPCR and Western blotting. B, Apoptosis of IMR32 cells with and without survivin overexpression following single and combination therapy for 24 hours. Survivin overexpression significantly attenuates the apoptosis induced by the combination therapy. C, Survivin protein levels are suppressed in IMR32 cells following YM155 treatment. Induction of apoptosis in IMR32 cells by the combination therapy with or without YM155 treatment for 24 hours. YM155 significantly potentiates the apoptotic response to the combination therapy.