Figure 3.

IL-35-producing B cells were associated with CD14⁺HLA-DR^low/– MDSCs in GC patients. Gating criteria from the peripheral blood for the CD14⁺HLA-DR^low/– MDSCs of GC patients are shown. (B) Representative data depicting the ratio of MDSCs in patients with different stages of GC are shown. (C) The frequency of IL-35-producing B cells was positively correlated with the frequency of CD14⁺HLA-DR^low/– MDSCs (r = 0.3973, P = .0492, n = 25). A correlation analysis was performed using Spearman rank correlation. GC = gastric cancer, IL-35 = Interleukin 35, MDSCs = myeloid-derived suppressor cells.