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. Author manuscript; available in PMC: 2018 Aug 21.
Published in final edited form as: Pediatr Res. 2018 Feb 21;83(5):1057–1066. doi: 10.1038/pr.2018.13

Figure 3. Survival and weight gain of reovirus-infected WT, IFNAR−/−, and RAG2−/− mice.

Figure 3

WT, IFNAR−/−, and RAG2−/− mice were inoculated intracranially with reovirus T3D at 100 PFU/g at either 4 or 15 d of age and monitored for morbidity for 20 d. Mice were euthanized when moribund. Survival of mice inoculated at (a) 4 and (b) 15 d of age. N ≥ 23 per experimental group. † P < 0.001 as determined by Log-rank test compared to WT. Weights of IFNAR−/− mice inoculated at (c) 4 or (d) 15 d of age. Weights of RAG2−/− mice inoculated at (e) 4 or (f) 15 d of age. N ≥ 15 per experimental group. *, P < 0.05; **, P < 0.01; †, P < 0.005; and ‡, P < 0.0001 as determined by Mann-Whitney U test.